Recently, multi-person video generation has started to gain prominence. While a few preliminary works have explored audio-driven multi-person talking video generation, they often face challenges due to the high costs of diverse multi-person data collection and the difficulty of driving multiple identities with coherent interactivity. To address these challenges, we propose AnyTalker, a multi-person generation framework that features a flexible multi-stream processing architecture. Specifically, we extend Diffusion Transformer's attention block with a novel identity-aware attention mechanism that iteratively processes identity–audio pairs, enabling the drivable IDs to scale arbitrarily. Besides, training multi-person generative models demands massive multi-person data. Our proposed training pipeline depends solely on single-person videos to learn multi-person speaking patterns and refines interactivity with only a few real multi-person clips. Furthermore, we contribute a targeted metric and dataset designed to evaluate the naturalness and interactivity of the generated multi-person videos. Extensive experiments demonstrate that AnyTalker achieves excellent lip synchronization, visual quality, and natural interactivity, striking a favorable balance between data costs and generation fidelity.